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VEGFR2/Flk-1 (D1209) polyclonal antibody

货号: BS1372

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS1372

Product Name :VEGFR2/Flk-1 (D1209) polyclonal antibody

Swiss-Prot :P35968

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF/ICC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF/ICC: 1:50~1:200

Background :Three cell membrane receptor tyrosine kinases, Flt (also designated VEGF-R1), Flk-1 (also designated VEGF-R2) and Flt-4, putatively involved in the growth of endothelial cells, are characterized by the presence of seven immunoglobulinlike sequences in their extracellular domain. These receptors exhibit high degrees of sequence relatedness to each other as well as lesser degrees of relatedness to the class III receptors including CSF-1/Fms, PDGR, SLFR/Kit and Flt-3/Flk-2. Two members of this receptor class, Flt-1 and Flk-1, have been shown to represent high affinity receptors for vascular endothelial growth factors (VEGFs). On the basis of structural similarity to Flt and Flk-1, it has been speculated that Flt-4 might represent a third receptor for either VEGF or a VEGF-related ligand.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :VEGFR2 (D1209) polyclonal antibody detects endogenous levels of VEGFR2 protein.

BiowMW :~ 180 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Tumor Angiogenesis,ErbB HER Signaling,ErbB HER Signaling,

Alternative Name :Vascular endothelial growth factor receptor 2; VEGFR-2; Fetal liver kinase 1; FLK-1; Kinase insert domain receptor; Protein-tyrosine kinase receptor flk-1; CD309; KDR; FLK1; VEGFR2

Immunogen :Synthetic peptide, corresponding to amino acids 1209-1250 of Human VEGFR2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of VEGFR2 expression in mouse heart (A), rat kidney (B), mouse kidney (C), HEK293T (D) whole cell lysates.

Immunohistochemistry (IHC) analyzes of VEGFR2 (D1209) pAb in paraffin-embedded human breast carcinoma tissue.

Immunofluorescent analysis of VEGFR2 staining in MCF7 cells.

Antiarthritic Effects of Sorafenib in Rats with Adjuvant‐Induced Arthritis

JournalAnatomical Record

ApplicationWB

IF1.329

SpeciesRat

PMID29752865