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VaV1 (A168) polyclonal antibody（KU）

货号: BS1370

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS1370

Product Name :VaV1 (A168) polyclonal antibody（KU）

Swiss-Prot :P15498

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :The Vav gene was originally identified on the basis of its oncogenic activation during the course of gene transfer assays. The major translational product of the Vav proto-oncogene has been identified as a protein containing an array of structural motifs. Contained within its amino terminus are a helix-loop-helix domain and a leucine zipper motif similar to that of Myc family proteins; deletion of this region of p95Vav causes its oncogenic activation. In addition, p95Vav contains an SH2 domain, which could indicate its role as a substrate for tyrosine kinases. Expression of p95Vav is limited exclusively to cells of hematopoietic origin, including those of the erythroid, lymphoid and myeloid lineages.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :VAV1 (A168) polyclonal antibody detects endogenous levels of VAV1 protein.

BiowMW :~ 100 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Actin Dynamics,

Alternative Name :Proto-oncogene vav; VAV1; VAV

Immunogen :Synthetic peptide, corresponding to amino acids 140-190 of Human VaV1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of VaV1 (A168) polyclonal antibody at 1:500 dilution Lane1:Hela whole cell lysate(40ug) Lane2:Jurkat whole cell lysate(40ug) Lane3:The spleen tissue lysate of Mouse(40ug) Lane4:The spleen tissue lysate of Rat(40ug)

Immunohistochemistry (IHC) analyzes of VaV1 (A168) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Novel role of Vav1-Rac1 pathway in actin cytoskeleton regulation in interleukin-13-induced minimal change-like nephropathy

JournalClinical Science

ApplicationIF

IF5.223

SpeciesRat,Human

PMID27707912