Product Name :TH (F34) polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :IHC: 1:50~1:200
IF: 1:50~1:200
Background :The enzyme tyrosine hydroxylase (TH), also designated tyrosine 3-monooxygenase (TY3H), catalyzes the conversion of tyrosine to L-dopa, which is the rate limiting step in the biosynthesis of catecholamines such as dopamine, adrenalin and noradrenalin. TH is thought to play a role in the pathogenesis of Parkinson’s disease, which is associated with reduced dopamine levels. Two transcription factor binding sites in the proximal region of the TH gene, the TPA-responsive element (TRE) and the c-AMP responsive element (CRE), have been implicated in the complex regulation of the TH gene. TH is also known to be upregulated by the glia maturation factor (GMF), a Cdc 10/SWI6 motif-containing protein called V-1, and a variety of additional compounds
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Tyrosine Hydroxylase (F34) polyclonal antibody detects endogenous levels of Tyrosine Hydroxylase protein.
Note :For research use only, not for use in diagnostic procedure.
Pathway :Neuronal and Glial Cell Marker Atlas,Dopamine Signaling in Parkinson's Disease Plathway,
Alternative Name :Tyrosine 3-monooxygenase; Tyrosine 3-hydroxylase; TH; TYH
Immunogen :Synthetic peptide, corresponding to amino acids 1-50 of Human TH.
Modification :Unmodification
