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TGFβ2 (L388) polyclonal antibody（KU）

货号: BS1362

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS1362

Product Name :TGFβ2 (L388) polyclonal antibody（KU）

Swiss-Prot :P61812

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Transforming growth factor betas (TGFβs) were originally discovered due to their ability to promote anchorage-independent growth of rat NRK fibroblasts in the presence of TGFα. It is now realized that TGFβs mediate many cell-cell interactions that occur during embryonic development. Three TGFβs have been identified in mammals. TGFβ1, TGFβ2 and TGFβ3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGFβ requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGFβ3 protein has approximately 80% identity to the mature region of both TGFβ1 and TGFβ2. However, the NH2 terminals or precursor regions of their molecules share only 27% sequence identity.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :TGF β2 (L388) polyclonal antibody detects endogenous levels of TGF β2 protein.

BiowMW :~ 48; 55 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Tumor Angiogenesis,Contribution of Soluble Factors to EMT,

Alternative Name :Transforming growth factor beta-2; TGF-beta-2; BSC-1 cell growth inhibitor; Cetermin; Glioblastoma-derived T-cell suppressor factor; G-TSF; Polyergin; Latency-associated peptide; LAP; TGFB2

Immunogen :Synthetic peptide, corresponding to amino acids 360-400 of Human TGFβ2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of TGFβ2 (L388) pAb at 1:500 dilution Lane1:HEK293T whole cell lysate(40ug) Lane2:A375 whole cell lysate(40ug) Lane3:MCF-7 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of TGFβ2 (L388) pAb in paraffin-embedded human lung carcinoma tissue at 1:100.

Ureic clearance granule, alleviates renal dysfunction and tubulointerstitial fibrosis by promoting extracellular matrix degradation in renal failure rats, compared with enalapril

JournalJournal Of Ethnopharmacology

ApplicationWB

IF4.36

SpeciesRat

PMID
HSPA12B promotes functional recovery after ischaemic stroke through an eNOS‐dependent mechanism

JournalJournal Of Cellular And Molecular Medicine

ApplicationWB

IF4.486

SpeciesMouse

PMID29411514