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Synaptotagmin (M303) polyclonal antibody（KU）

货号: BS1347

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS1347

Product Name :Synaptotagmin (M303) polyclonal antibody（KU）

Swiss-Prot :P21579

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Synaptotagmins are a large gene family of synaptic vesicle type III integral membrane proteins that function as regulators of both exocytosis and endocytosis and are involved in neurotransmitter secretion from small secretory vesicles. Calcium binds to Synaptotagmin I which triggers neurotransmitter release at the synapse. Synaptotagmin II is phosphorylated by WNK1 in a process that regulates calcium-dependent interactions. Synaptotagmin III is involved in calcium-dependent exocytosis of secretory vesicles in endocrine cells and neurons. Synaptotagmin IV is expressed in neuronal tissues, and has the highest mRNA levels in the hippocampus.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Synaptotagmin (M303) polyclonal antibody detects endogenous levels of Synaptotagmin protein.

BiowMW :~ 64 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Vesicle Trafficking presynaptic signaling,

Alternative Name :Synaptotagmin-1; Synaptotagmin 1; Synaptotagmin I; SytI; SYT1; SVP65; SYT

Immunogen :Synthetic peptide, corresponding to amino acids 280-330 of Human Synaptotagmin.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Synaptotagmin (M303) polyclonal antibody at 1:500 dilution Lane1:Hela whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:H9C2 whole cell lysate

Immunohistochemistry (IHC) analyzes of Synaptotagmin (M303) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

ROS induces epithelial‑mesenchymal transition via the TGF‑β1/PI3K/Akt/mTOR pathway in diabetic nephropathy

JournalExperimental and Therapeutic Medicine

ApplicationWB

IF2.447

SpeciesRat

PMID30651870