Product Name :Synaptotagmin (T196) polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :IHC: 1:50~1:200
Background :Synaptotagmins are a large gene family of synaptic vesicle type III integral membrane proteins that function as regulators of both exocytosis and endocytosis and are involved in neurotransmitter secretion from small secretory vesicles. Calcium binds to Synaptotagmin I which triggers neurotransmitter release at the synapse. Synaptotagmin II is phosphorylated by WNK1 in a process that regulates calcium-dependent interactions. Synaptotagmin III is involved in calcium-dependent exocytosis of secretory vesicles in endocrine cells and neurons. Synaptotagmin IV is expressed in neuronal tissues, and has the highest mRNA levels in the hippocampus.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Synaptotagmin (T196) polyclonal antibody detects endogenous levels of Synaptotagmin protein.
Note :For research use only, not for use in diagnostic procedure.
Pathway :Vesicle Trafficking presynaptic signaling,
Alternative Name :Synaptotagmin-1; Synaptotagmin 1; Synaptotagmin I; SytI; SYT1; SVP65; SYT
Immunogen :Synthetic peptide, corresponding to amino acids 170-220 of Human Synaptotagmin.
Modification :Unmodification
