Product Name :Na+ CP-pan (K1493) polyclonal antibody
Swiss-Prot :P35498/Q99250/Q9NY46/P35499/Q14524/Q9UQD0/Q15858/Q9Y5Y9/Q9UI33
Reactivity :Human,Mouse,Rat
Application_all :IHC: 1:50~1:200
IF: 1:50~1:200
Background :Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddel’s syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1).
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Sodium Channel-pan (K1493) polyclonal antibody detects endogenous levels of Sodium Channel-pan protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :SCN2A; NAC2, SCN2A1, SCN2A2; Nav1.1; NAC1; SCN1; SCN1A; Nav1.2; SCN3A; KIAA1356, NAC3; Nav1.3; Nav1.4; SCN4A; Nav1.5; SCN5A; Nav1.6; SCN8A; MED; Nav1.7; SCN9A; NENA; Nav1.8; SCN10A; Nav1.9; hNaN; SCN11A; SCN12A; SNS2
Immunogen :Synthetic peptide, corresponding to amino acids 1470-1520 of Human SCN5A.
Modification :Unmodification
