Product Name :PRPH (S454) polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :IHC: 1:50~1:200
Background :Peripherin is a type III intermediate filament protein that is expressed in peripheral and some central nervous system (CNS) neurons. Peripherin activation is known to be induced by leukemia inhibitory factor (LIF). LIF activates Peripherin by inducing members of STAT transcription factor family to bind to a specific promoter element in the Peripherin gene. IL-6 is also known to induce Peripherin expression. Although it is not essential for neurite formation, peripherin is necessary for cellular intermediate filament network formation. Peripherin, unlike most intermediate filament proteins, has been reported to be modified by tyrosine phosphorylation
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :PRPH (S454) polyclonal antibody detects endogenous levels of Peripherin protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Peripherin; Neurofilament 4; PRPH; NEF4; PRPH1
Immunogen :Synthetic peptide, corresponding to amino acids 430-480 of Human PRPH.
Modification :Unmodification
