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MMP-13 (L22) polyclonal antibody

货号: BS1231

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS1231

Product Name :MMP-13 (L22) polyclonal antibody

Swiss-Prot :P45452

Host :Rabbit

Reactivity :Human

Applications :WB IHC IF

Application_all :WB: 1:500~1:2000 IHC: 1:50~1:200 IF: 1:200

Background :The matrix metalloproteinases (MMP) are a family ofpeptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibroPVRL1, laminin and proteoglycan. Transcriptionof MMP genes is differentially activated by phorbol ester,lipopolysaccharide (LPS) or staphylococcal enterotoxin B(SEB). MMP catalysis requires both calcium and zinc.MMP-13 (also designated collagenase-3) is produced bybreast carcinomas and degrades collagen types I, II andIII. MMP-13 has wide substrate specificity, and its physiologic expression is limited to situations in which rapidand effective remodeling of collagenous ECM takesplace, such as fetal bone development and adult bone remodeling

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Ac-Histone H3 (K18) polyclonal antibody detects endogenous levels of Histone H3 protein only when acetylated at Lys18.

BiowMW :~ 17 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Histone H3.1; HIST1H3A; H3FA; HIST1H3B; H3FL; HIST1H3C; H3FC; HIST1H3D; H3FB; HIST1H3E; H3FD; HIST1H3F; H3FI; HIST1H3G; H3FH; HIST1H3H; H3FK; HIST1H3I; H3FF; HIST1H3J; H3FJ; Histone H3.2; Histone H3/m; Histone H3/o; HIST2H3A; HIST2H3C; H3F2; H3FM; HIST2H3D; Histone H3.3; H3F3A; H3.3A; H3F3; H3F3B; H3.3B

Immunogen :Synthetic peptide including acetyl-lysine 18 of Histone H3.

Conjugate :Unconjugated

Modification :Acetylated

Western blot analysis of extracts from HeLa cells, treated with TSA 400nM 24h, using Histone H3 (Acetyl-K18) Antibody. The lane on the left is treated with the synthesized peptide.

Proteoglycans Enhance the Therapeutic Effect of BMSC Transplantation on Osteoarthritis

Journal10.3390/bioengineering11111167

ApplicationIHC

IF3.8

SpeciesRat

PMID39593826