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MMP-11 (G88) polyclonal antibody

货号: BS1230

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS1230

Product Name :MMP-11 (G88) polyclonal antibody

Swiss-Prot :P24347

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :IHC IF

Application_all :IHC: 1:50~1:200 IF: 1:50~1:200

Background :The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or taphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-3, MMP-10 and MMP-11 (also designated stromelysin- 1, -2 and -3) activate procollagenase. MMP-3 activation of procollagenase can occur via two pathways. Direct activation by MMP-3 is slow and activation by MMP-3 in conjunction with tissue or plasma proteinases is rapid. MMP-10 is expressed in small intestine, and it is expressed at lower levels in lung and heart. MMP-11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :MMP-11 (G88) polyclonal antibody detects endogenous levels of MMP-11 protein.

BiowMW :~ 55 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Stromelysin-3; Stromelysin 3; Stromelysin3; SL-3; ST3; Matrix metalloproteinase-11; MMP-11; MMP11; STMY3

Immunogen :Synthetic peptide, corresponding to amino acids 55-100 of Human MMP-11.

Conjugate :Unconjugated

Modification :Unmodification

Immunohistochemistry (IHC) analyzes of MMP-11 (G88) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Automated Analysis and Classification of Histological Tissue Features by Multi-Dimensional Microscopic Molecular Profiling

JournalPLoS One

ApplicationIF

IF2.74

SpeciesHuman

PMID26176839
miR‐125a‐3p suppresses the growth and progression of papillary thyroid carcinoma cell by targeting MMP11

JournalJournal Of Cellular Biochemistry

ApplicationIHC

IF3.448

SpeciesHuman

PMID31489990