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JAK1 polyclonal antibody

货号: BS1193

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS1193

Product Name :JAK1 polyclonal antibody

Swiss-Prot :P23458

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IF IHC

Application_all :WB: 1:500~1:1000 IF: 1:50~1:200 IHC: 1:50~1:200

Background :Members of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3, and Tyk2) are activated by ligands binding to a number of associated cytokine receptors. Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their associated receptors to provide multiple binding sites for signaling proteins. These associated signaling proteins, such as Stats, Shc, insulin receptor substrates, and focal adhesion kinase (FAK), typically contain SH2 or other phospho-tyrosine-binding domains.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :JAK1 polyclonal antibody detects endogenous levels of JAK1 protein.

BiowMW :~ 125 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Jak Stat ：IL-6 Receptor Signaling,Inhibition of Apoptosis,

Alternative Name :Tyrosine-protein kinase JAK1; Janus kinase 1; JAK-1; JAK1; JAK1A; JAK1B

Immunogen :Synthetic peptide, corresponding to Human JAK1.

Conjugate :Unconjugated

Modification :Unmodification

Immunofluorescent (IF) analyzes of JAK1 pAb in Jurkat at 1:50.

Immunohistochemistry (IHC) analyzes of JAK1 pAb in paraffin-embedded human breast cancer tissue at 1:50.

Neuronal MHC Class I Expression Is Regulated by Activity Driven Calcium Signaling

JournalPLoS One

ApplicationWB

IF2.776

SpeciesMouse

PMID26263390
Andrographolide Inhibition of Th17-Regulated Cytokines and JAK1/STAT3 Signaling in OVA-Stimulated Asthma in Mice

JournalEvidence-based Complementary and Alternative Medicine

ApplicationWB

IF2.629

SpeciesMouse

PMID34194525
Traditional Chinese medicine CFF-1 exerts a potent anti-tumor immunity to hinder tumor growth and metastasis in prostate cancer through EGFR/JAK1/STAT3 pathway to inhibit PD-1/PD-L1 checkpoint signaling

JournalPhytomedicine

ApplicationWB,IHC

IF5.34

SpeciesMouse,Human

PMID35172257
Dapagliflozin protects against nonalcoholic steatohepatitis in db/db mice.

JournalFrontiers in Pharmacology

ApplicationWB

IF5.988

SpeciesMouse

PMID36059948
Transglutaminase 2 regulates endothelial cell calcification via IL-6-mediated autophagy

Journal10.3389/fphar.2024.1393534

ApplicationWB

IF4.4

SpeciesHuman

PMID39654623