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COPS3 (M408) polyclonal antibody（KU）

货号: BS1192

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS1192

Product Name :COPS3 (M408) polyclonal antibody（KU）

Swiss-Prot :Q9UNS2

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :The COP9 signalosome (CSN) complex is involved in several different developmental and cellular processes. The complex is made up of several widely expressed proteins: CSN1 (COPS1), CSN2 (COPS2), CSN3 (COPS3), CSN4 (COPS4), CSN5 (COPS5), CSN6 (COP6), CSN7a (COPS7, COPS7a) or CSN7b (COP7b) and CSN8 (COP8). The CSN complex acts as a regulator for the ubiquitin conjugation pathway by mediating the deneddylation of the SCF-type E3 ligase complexes, which leads to a decrease in ubiquitin ligase activity of SCF-complexes. It is also involved in the phosphorylation of p53, c-Jun, I˚Bα and IRF-8, as well as CSN-dependent phosphorylation of p53, and c-Jun protects and promotes degradation by the Ubl system.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :COPS3 (M408) polyclonal antibody detects endogenous levels of COPS3 protein.

BiowMW :~ 47 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :COP9 signalosome complex subunit 3; SGN3; Signalosome subunit 3; AB1-containing signalosome subunit 3; COPS 3; CSN3

Immunogen :Synthetic peptide, corresponding to amino acids 376-425 of Human COPS3.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of COPS3 (M408) polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate Lane2:sp2/0 cell lysate Lane3:Mouse liver tissue lysate Lane4:Rat liver tissue lysate

Immunohistochemistry (IHC) analyzes of COPS3 (M408) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Novel oncogene COPS3 interacts with Beclin1 and Raf-1 to regulate metastasis of osteosarcoma through autophagy

JournalJournal Of Experimental & Clinical Cancer Research

ApplicationIHC

IF5.646

SpeciesHuman,Mouse

PMID29970115
Knockdown of COPS3 inhibits the progress of prostate cancer through reducing phosphorylated p38 MAPK expression and impairs the epithelial‐mesenchymal transition process

JournalProstate

ApplicationWB,IHC

IF3.279

SpeciesHuman

PMID31509289