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SLC2A1 polyclonal antibody

货号: BS1149

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS1149

Product Name :SLC2A1 polyclonal antibody

Swiss-Prot :P11166

Host :Rabbit

Reactivity :Human,Rat

Applications :WB

Application_all :WB: 1:1000~1:2000

Background :Glucose transporter 1 (Glut1, SLC2A1) is a widely expressed transport protein that displays a broad range of substrate specificity in transporting a number of different aldose sugars as well as an oxidized form of vitamin C into cells . Glut1 is responsible for the basal-level uptake of glucose from the blood through facilitated diffusion . Research studies show that Glut1 and the transcription factor HIF-1α mediate the regulation of glycolysis by O-GlcNAcylation in cancer cells . Additional studies demonstrate that Glut1 is required for CD4 T cell activation and is critical for the expansion and survival of T effector (Teff) cells . Mutations in the corresponding SLC2A1 gene cause GLUT1 deficiency syndromes (GLUT1DS1, GLUT1DS2), a pair of neurologic disorders characterized by delayed development, seizures, spasticity, paroxysmal exercise-induced dyskinesia, and acquired microcephaly . Two other neurologic disorders - dystonia-9 (DYT9) and susceptibility to idiopathic generalized epilepsy 12 (EIG12) - are also caused by mutations in the SLC2A1 gene .

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :SLC2A1 polyclonal antibody detects endogenous levels of SLC2A1 protein.

BiowMW :~ 50 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Warburg Effect,Insulin &Glucose Signaling,Glutamine Metabolism,

Alternative Name :Solute carrier family 2, facilitated glucose transporter member 1;Glucose transporter type 1, erythrocyte/brain; GLUT-1; SLC2A1;

Immunogen :Synthetic peptide, corresponding to Human SLC2A1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of SLC2A1 polyclonal antibody at 1:500 dilution Lane1:PC12 whole cell lysate(40ug) Lane2:SGC7901 whole cell lysate(40ug) Lane3:EC9706 whole cell lysate(40ug)

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