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TFDP1 (V393) polyclonal antibody（KU）

货号: BS1093

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS1093

Product Name :TFDP1 (V393) polyclonal antibody（KU）

Swiss-Prot :Q14186

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :The human retinoblastoma gene product appears to play an important role in the negative egulation of cell proliferation. Functional inactivation of Rb can be mediated either through mutation or as a consequence of interaction with DNA tumor virus-encoded proteins. Of all the Rb associations described to date, the identification of a complex between Rb and the transcription factor E2F most directly implicates Rb in regulation of cell proliferation. E2F was originally identified through its role in transcriptional activation of the adenovirus E2 promoter. Sequences homologous to the E2F binding site have been found upstream of a number of genes that encode proteins with putative functions in the G1 and S phases of the cell cycle. E2F-1 forms heterodimers with a second protein, designated DP-1, forming an “active” E2F transcriptional regulatory complex. Additional members of the E2F family include E2F-2, E2F-3, E2F-4, E2F-5 and DP-2.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :TFDP1 (V393) polyclonal antibody detects endogenous levels of TFDP1 protein.

BiowMW :~ 43 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Cell Cycle Control G1 S Checkpoint,

Alternative Name :Transcription factor Dp-1; DRTF1-polypeptide 1; DRTF1; E2F dimerization partner 1; TFDP1; DP1

Immunogen :Synthetic peptide, corresponding to amino acids 360-418 of Human TFDP1.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of TFDP1 (V393) pAb at 1:500 dilution Lane1:SGC7901 whole cell lysate(40ug) Lane2:A375 whole cell lysate(40ug) Lane3:MCF-7 whole cell lysate(40ug) Lane4:The Muscle tissue lysate of Mouse(40ug)

Immunohistochemistry (IHC) analyzes of TFDP1 (V393) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.