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DNA-PKCS (R4090) polyclonal antibody（KU）

货号: BS1092

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS1092

Product Name :DNA-PKCS (R4090) polyclonal antibody（KU）

Swiss-Prot :P78527

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :The phosphatidylinositol kinase (PIK) family members fall into two distinct subgroups. The first subgroup contains proteins such as the PI 3- and PI 4-kinases and the second group comprises the PIK-related kinases. The PIK-related kinases include Atm, DNA-PKCS and FRAP. These proteins have in common a region of homology at their carboxy termini that is not present in the PI 3- and PI 4-kinases. All of the members of the PIK-related kinases are also over 270 kDa. The Atm gene is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) that is characterized by cerebellar degeneration (ataxia) and the appearance of dilated blood vessels (telangiectases) in the conjunctivae of the eyes.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :DNA-PKCS (R4090) polyclonal antibody detects endogenous levels of DNA-PKCS protein.

BiowMW :~ 450 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Insulin &Glucose Signaling,Cell Cycle G2 M DNA Damage Signaling Pathway,

Alternative Name :DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; DNA-PKcs; DNPK1; p460; PRKDC; HYRC; HYRC1

Immunogen :Synthetic peptide, corresponding to amino acids 4060-4110 of Human DNA-PKCS.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of DNA-PKCS (R4090) pAb at 1:500 dilution Lane1:MCF-7 whole cell lysate(15ug) Lane2:A549 whole cell lysate(15ug) Lane3:CT26 whole cell lysate(40ug) Lane4:The Lung tissue lysate of Rat(40ug)

Immunohistochemistry (IHC) analyzes of DNA-PKCS (R4090)pAbb in paraffin-embedded human breast carcinoma tissue at 1:100.