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PARK7 (P54) polyclonal antibody（KU）

货号: BS1090

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS1090

Product Name :PARK7 (P54) polyclonal antibody（KU）

Swiss-Prot :Q99497

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :The DJ-1 gene encodes a highly-conserved protein which is implicated in a number of cell processes. DJ-1 was first identified as a novel oncogene that transformed mouse NIH/3T3 cells in cooperation with activated Ras. Additionally, DJ-1 was cloned in rat as SP22 or CAP-1 and found to be an infertilityrelated sperm protein, whose expression is reduced in sperm treated with toxicants. DJ-1 also positively regulates the androgen receptor (AR) by forming a complex with PIASxα, a negative regulator of AR. The gene encoding human DJ-1 maps to chromosome 1p36.33-p36.12, a region identified as a hot spot of chromosome abnormalities in several tumor cells. Subsequently, mutations in the DJ-1 gene have been implicated in Parkinson’s disease, and loss of DJ-1 function leads to neurodegeneration. DJ-1 is an ubiquitously expressed protein that is induced in response to growth stimuli and translocates from the cytoplasm to the nucleus during the S phase of the cell cycle.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :PARK7 (P54) polyclonal antibody detects endogenous levels of PARK7 protein.

BiowMW :~ 22 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Dopamine Signaling in Parkinson's Disease Plathway,

Alternative Name :Protein DJ-1; Oncogene DJ1; Parkinson disease protein 7; PARK7

Immunogen :Synthetic peptide, corresponding to amino acids 22-70 of Human PARK7.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of PARK7 (P54) polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate(20ug) Lane2:HepG2 whole cell lysate(20ug) Lane3:LO2 whole cell lysate(20ug) Lane4:The testis tissue lysate of Mouse(40ug) Lane5:The testis tissue lysate of Rat(40ug)

Immunohistochemistry (IHC) analyzes of PARK7 (P54) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.