产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

COX-2 (T594) polyclonal antibody（KU）

货号: BS1076

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS1076

Product Name :COX-2 (T594) polyclonal antibody（KU）

Swiss-Prot :P35354

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate in formation of the prostaglandins. Two prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA) are cyclooxygenase-1 and cyclooxygenase-2. Cyclooxygenase-2, or Cox-2, is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. An alternative form of the protein, designated Cox-1, is constitutively expressed in most tissues and is thought to serve in general “housekeeping” functions. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatorydrugs, NSAIDs.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Cox2 (T594) polyclonal antibody detects endogenous levels of Cox2 protein.

BiowMW :~ 74 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Immune Cell Signaling,

Alternative Name :Prostaglandin G/H synthase 2; Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; PGHS2; Prostaglandin-endoperoxide synthase 2; PTGS2; COX2

Immunogen :Synthetic peptide, corresponding to amino acids C-terminus of Human Cox-2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Cox-2 (T594) polyclonal antibody at 1:500 dilution Lane1:CT26 whole cell lysate(20ug) Lane2:PC12 whole cell lysate(40ug) Lane3:Hela whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of Cox-2 (T594) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Berberine Protects Secondary Injury in Mice with Traumatic Brain Injury Through Anti-oxidative and Anti-inflammatory Modulation

JournalNeurochemical Research

ApplicationIHC

IF2.782

SpeciesMouse

PMID30027364
Dapagliflozin protects against nonalcoholic steatohepatitis in db/db mice.

JournalFrontiers in Pharmacology

ApplicationWB

IF5.988

SpeciesMouse

PMID36059948
Exposure of newborns to atmospherically relevant artificial particulate matter induces hematopoietic stem cell senescence

JournalJOURNAL OF HAZARDOUS MATERIALS

ApplicationIHC

IF14.224

SpeciesMouse

PMID37002998
(+)-Borneol exerts neuroprotective effects via suppressing the NF-κB pathway in the pilocarpine-induced epileptogenesis rat model

JournalBRAIN RESEARCH

ApplicationWB

IF3.61

SpeciesRat

PMID37127175
Anti-oxidant and Anti-inflammatory Effects of Ethanol Extract from Polygala sibirica L. var megalopha Fr. on Lipopolysaccharide-Stimulated RAW264.7 Cells

JournalChinese Journal of Integrative Medicine

ApplicationWB

IF2.9

SpeciesMouse

PMID37434032