产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

Claudin-5 (S201) polyclonal antibody（KU）

货号: BS1069

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS1069

Product Name :Claudin-5 (S201) polyclonal antibody（KU）

Swiss-Prot :O00501

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :The Claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. Claudin expression is highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions. Claudin-5 is expressed in the endothelial junctions of the rat liver and in junctions of acinar cells of the pancreas. Human claudin-5 is abundantly expressed in adult lung, heart and skeletal muscle and is deleted in patients with velocardiofacial syndrone, which is characterized by cleft palate, facial dysmorphology and conotruncal heart defects.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Claudin 5 (S201) polyclonal antibody detects endogenous levels of Claudin 5 protein.

BiowMW :~ 23 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Claudin5; Claudin 5; Transmembrane protein deleted in VCFS; TMDVCF; CLDN5; AWAL; TMVCF

Immunogen :Synthetic peptide, corresponding to amino acids 171-220 of Human Claudin-5.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Claudin-5 (S201) polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate treated with LPS Lane2:Mouse liver tissue lysate Lane3:Rat lung tissue lysate

Immunohistochemistry (IHC) analyzes of Claudin-5 (S201) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Disruption of endothelial barrier function is linked with hyposecretion and lymphocytic infiltration in salivary glands of Sjögren's syndrome

JournalBiochimica Et Biophysica Acta-Molecular Basis Of Disease

ApplicationIF

IF5.187

SpeciesHuman,Mouse

PMID29981359
The Effect of Chronic Cerebral Hypoperfusion on Blood-Brain Barrier Permeability in a Transgenic Alzheimer’s Disease Mouse Model (PS1V97L)

JournalJournal Of Alzheimers Disease

ApplicationIHC,WB

IF4.472

SpeciesMouse

PMID32007956
Total Glycosides of Cistanche deserticola Promote Neurological Function Recovery by Inducing Neurovascular Regeneration via Nrf-2/Keap-1 Pathway in MCAO/R Rats

JournalFrontiers in Pharmacology

ApplicationIF

IF4.225

SpeciesRat

PMID32256351
Calcium dobesilate reduces VEGF signaling by interfering with heparan sulfate binding site and protects from vascular complications in diabetic mice

JournalPLoS One

ApplicationWB

IF2.74

SpeciesHuman

PMID31935212
Hydroxychloroquine attenuates neuroinflammation following traumatic brain injury by regulating the TLR4/NF-κB signaling pathway

JournalJournal of Neuroinflammation

ApplicationWB

IF8.322

SpeciesMouse

PMID35346242