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Claudin 1 (R197) polyclonal antibody

货号: BS1063

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS1063

Product Name :Claudin 1 (R197) polyclonal antibody

Swiss-Prot :O95832

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :The claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the claudins, Occludin and junction adhesion molecule (JAM). Claudins, which consist of four transmembrane domains and two extracellular loops, make up tigh junction strands. Emerging evidence suggests that the claudin family of proteins regulates transport through tight junctions via differential discrimination for solute size and charge. Claudin expression is often highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Claudin 1 (R197) polyclonal antibody detects endogenous levels of Claudin 1 protein.

BiowMW :~ 22 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Contribution of ECM and Cytoskeletal Factors to EMT,

Alternative Name :Claudin-1; CLD1; ILVASC; SEMP1; Claudin1; CLDN1; UNQ481/PRO944

Immunogen :Synthetic peptide, corresponding to amino acids 171-220 of Human Claudin-1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Claudin 1 (R197) pAb at 1:500 dilution Lane1:PC12 whole cell lysate(40ug) Lane2:The Liver tissue lysate of Mouse(40ug) Lane3:The Kidney tissue lysate of Rat(20ug) Lane4:L02 whole cell lysate(40ug) Lane5:H1792 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of Claudin-1 (R197) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

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