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PD1 monoclonal antibody (Humanized)

货号: AP6666

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :AP6666

Product Name :PD1 monoclonal antibody (Humanized)

Swiss-Prot :Q15116

Host :Human

Reactivity :Human

Applications :Neutralization/Block

Application_all :Neutralization/Block

Background :The humanized monoclonal anti-PD1 antibody can effectively block the combination between PDL1 and PD1, and will not cause HAMA reaction (anti mouse antibody response). Programmed cell death protein 1 (PD-1) (UniProt Q15116), is a type I single transmembrane protein encoded by the PDCD1 gene in human. T-cell activation is generally self-limited as activated T cells express receptors such as PD-1. Maintenance of peripheral tolerance by preventing the development of autoimmunity due to T lymphocytes specific for self-antigens is essential for homeostasis of the immune system. PD-1 can bind two different but related ligands, PDL-1 and PDL-2.PD-1 receptor and its ligands PD-L1 and PD-L2play a vital role in the induction and maintenance of peripheral tolerance. The humanized monoclonal anti-PD1 antibody has demonstrated durable antitumor activity.

Product :1mg/ml in PBS with 50% Glycerol.

Purification&Purity :Recombinant IgG antibodies were expressed and secreted by 293F cells and purified by Protein A.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :PD1 monoclonal antibody (Humanized) detects endogenous levels of human PD1 protein. Variable region genes (including VH &VL) of this antibody were derived from a single B cell by PCR.

BiowMW :~ 32 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Immune checkpoint signaling in the Tumor Microenvironment,Tumor-Infiltrating Immune Cell Marker Guide,T cell receptor signaling,

Alternative Name :Programmed cell death protein 1; Protein PD-1; hPD-1; CD279; PDCD1; PD1

Immunogen :Variable region genes (including VH &VL) of this antibody were derived from a single B cell by PCR.

Conjugate :Unconjugated

Modification :Unmodification

Western blot shows binding reaction of PD1 monoclonal antibody (Humanized) and recombinant human PD1 (with Fc tag). Recombinant human PD1 (Fc) was electrophoresed by SDS-PAGE and transferred on PVDF membrane. PVDF membrane was probed with PD1 monoclonal antibody (Humanized) followed by HRP-conjugated Anti-Human IgG Fab secondary Antibody.