Product Name :Substance P polyclonal antibody（KU）
Reactivity :Human,Mouse,Rat
Application_all :IHC: 1:100~1:500
IF: 1:100~1:500
Background :Substance P (also designated NK-1) is an active peptide, known as a Tachykinin, that affects diverse functions, including blood pressure regulation, peristalsis of the gut, salivation and the modulation of cellular immunity. Frag-ments of Substance P have differential binding capacities for Substance P receptors and have varying biological activities. For example, two amino- terminal fragments of Substance P are able to evoke an increase in GABA release. NK-1 receptor (NK-1R), also designated Substance P receptor, binds to Tachykinin peptides, including Substance P, Substance K and Neuromedin K. In response to Substance P binding, NK-1R signals IL-12 production.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 96% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Substance P polyclonal antibody reacts specifically with Substance P. No crossreactivity with related tachykinins (Neurokinin A, Neurokinin B, and Kassinin).
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Protachykinin-1; PPT; TAC1; SP
Immunogen :Synthetic peptide, corresponding to mature of Substance P of human origin.
Modification :Unmodification
