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Raptor (phospho-Ser792) polyclonal antibody（KU）

货号: AP4001

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :AP4001

Product Name :Raptor (phospho-Ser792) polyclonal antibody（KU）

Swiss-Prot :Q8N122

Host :Rabbit

Reactivity :Human,Mouse

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Regulatory associated protein of FRAP, also designated Raptor, is a binding partner for mammalian target of rapamycin kinase (FRAP), and is essential for FRAP signalling in vivo. Raptor binding to FRAP is critical for FRAP-catalysed substrate phosphorylation of 4E-BP1. The raptor-FRAP complex is nutrient-sensitive and is important for a mechanism by which cells coordinate cell growth and size with changing environmental conditions. Raptor serves as a negative regulator of FRAP kinase activity under nutrient-deprived conditions and is an important component in the FRAP pathway. Raptor is highly expressed in skeletal muscle and to a lesser extent in brain, kidney, lung and placenta.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :A phospho specific peptide corresponding to residues surrounding Ser792 of human RPTOR

BiowMW :~ 150 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Phosphoinosotode Signaling,PI3K AKT signaling,Insulin &Glucose Signaling,Glutamine Metabolism,MTOR signaling,

Alternative Name :Regulatory-associated protein of mTOR; Raptor; p150 target of rapamycin (TOR)-scaffold protein; RPTOR; KIAA1303; RAPTOR

Immunogen :Synthetic phosphopeptide derived from human Raptor around the phosphorylation site of Ser792.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot analysis of extracts of 293T cells, using Phospho-Raptor-Ser792 antibody at 1:1000 dilution.293T cells were treated by Oligomycin (0.5 uM) at 37℃ for 30 minutes after serum-starvation overnight. Lysates/proteins: 25ug per lane.