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Occludin (A23) polyclonal antibody

货号: AP0765

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :AP0765

Product Name :Occludin (A23) polyclonal antibody

Swiss-Prot :Q16625

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Occludin is an integral membrane protein closely associated with the tight junctions of epithelial and endothelial cells. Occludin is a tetraspan integral membrane protein in epithelial and endothelial tight junction (TJ) structures that can contain two extracellular loops. The protein exists in a variety of phosphorylated forms. Phosphorylation is involved in regulating both the localization and the function of occludin. Expression of occludin is up-regulated by polyunsaturated fatty acids, increasing transendothelial cell resistance and reducing cellular permeability to large molecules. The level of occludin varies greatly depending on tissue; in brain tissue, occludin is highly expressed at cell-cell contact sites.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Occludin (A23) polyclonal antibody detects endogenous levels of Occludin protein.

BiowMW :~ 59 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :OCLN

Immunogen :A synthetic peptide corresponding to residues in Human Occludin.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Occludin (A23) polyclonal antibody at 1:1000 dilution Lane1:Hela whole cell lysate(40ug) Lane2:PC12 whole cell lysate(40ug) Lane3:The Kidney tissue lysate of Mouse(30ug) Lane4:The Kidney tissue lysate of Rat(30ug)

Atorvastatin alleviates microglia-mediated neuroinflammation via modulating the microbial composition and the intestinal barrier function in ischemic stroke mice

JournalFree Radical Biology And Medicine

ApplicationWB

IF6.17

SpeciesMouse

PMID33279615