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Caspase-8 (T341) polyclonal antibody

货号: AP0358

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :AP0358

Product Name :Caspase-8 (T341) polyclonal antibody

Swiss-Prot :Q14790

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase 8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase 3 and Caspase 7, which in turn cause cell collapse.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Caspase-8 (T341) polyclonal antibody detects endogenous levels of Caspase-8 protein.

Note :~ 55 kDa

Pathway :For research use only, not for use in diagnostic procedure.

Alternative Name :MCH5; Caspase-8; CASP-8; Apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; FLICE; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; MACH

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Caspase 8.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of Caspase 8 expression in HEK293T (A), PC3 (B), Hela (C) whole cell lysates.

Nuclear respiratory factor 1 protects H9C2 cells against hypoxia-induced apoptosis via the death receptor pathway and mitochondrial pathway

JournalCell Biology International

ApplicationWB

IF3.612

SpeciesRat

PMID33913583
Polysaccharides from Nostoc commune Vaucher activate macrophages via NF-κB and AKT/JNK1/2 pathways to suppress colorectal cancer growth in vivo

JournalFood & Function

ApplicationIHC,WB

IF3.241

SpeciesHuman

PMID31259992