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SSB (phospho-S366) polyclonal antibody（KU）

货号: AP0349

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :AP0349

Product Name :SSB (phospho-S366) polyclonal antibody（KU）

Swiss-Prot :P05455

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB: 1:1000~1:2000

Background :Ro/SSA is a ribonucleoprotein that binds to autoantibodies in 35 to 50% of patients with SLE and in up to 97% of patients with Sjogren syndrome. The Ro/SSA particle consists of a single immunoreactive protein noncovalently bound with one of four small RNA molecules. Most anti-Ro/SSA-positive sera have antibodies not only against the immunoreactive protein, but also against an Ro/SSA protein. The genes which encode the two proteins map to human chromosomes 11p15.5 and 1q31, respectively. La/SSB is an autoimmune RNA-binding protein that plays a role in the transcription of RNA polymerase III was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome and SLE.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 110% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :p-SSB (S366) polyclonal antibody detects endogenous levels of SSB protein only when phosphorylated at Serine 366.

BiowMW :~ 52 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Autoantigen La; La; La autoantigen; La autoantigen homolog; La protein; La ribonucleoprotein; La ribonucleoprotein domain family member 3; LA; LARP3; Lupus La antigen; Lupus La protein; Lupus La protein homolog; mRNA for autoantigen; Sjoegren syndrome type B antigen; Sjoegren syndrome type B antigen; Sjogren syndrome antigen B; SS B; SS-B; SS-B/La protein; SSB;

Immunogen :Synthetic phosphopeptide derived from human SSB around the phosphorylation site of Serine 366.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of p-SSB (S366) polyclonal antibody at 1:1000 dilution Lane1:HEK293T whole cell lysate Lane2:HEK293T treated with EGF(0.1ng/ml,15min) whole cell lysate Lane3:HEK293T treated with EGF(0.1ng/ml,30min) whole cell lysate Lane4:HEK293T treated with EGF(0.1ng/ml,60min) whole cell lysate