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c-IAP1 polyclonal antibody（KU）

货号: AP0045

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :AP0045

Product Name :c-IAP1 polyclonal antibody（KU）

Swiss-Prot :Q13490

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB: 1:2000~1:5000

Background :The inhibitor of apoptosis protein (IAP) family consists of an evolutionarily conserved group of apoptosis inhibitors containing a conserved 70 amino acid BIR (baculovirus inhibitor repeat) domain. Human members of this family include c-IAP1, c-IAP2, XIAP, survivin, livin, and NAIP. Overexpression of IAP family members, particularly survivin and livin, in cancer cell lines and primary tumors suggests an important role for these proteins in cancer progression. In general, the IAP proteins function through direct interactions to inhibit the activity of several caspases, including caspase-3, caspase-7, and caspase-9. In addition, binding of IAP family members to the mitochondrial protein Smac blocks their interaction with caspase-9, thereby allowing the processing and activation of the caspase.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :c-IAP1 polyclonal antibody detects endogenous levels of c-IAP1 protein.

BiowMW :~ 62 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Apoptosis,Necrotic Cell Death,Death Receptor Signaling,

Alternative Name :Baculoviral IAP repeat-containing protein 2; Cellular inhibitor of apoptosis; C-IAP1; hIAP-2; Hiap2; RING finger protein 48; RING-type E3 ubiquitin transferase BIRC2; TNFR2-TRAF-signaling complex protein 2

Immunogen :Synthetic peptide, corresponding to Human c-IAP1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of TGFβ c-IAP1 polyclonal antibody at 1:2000 dilution Lane1:HCT116 whole cell lysate(40ug) Lane2:K562 whole cell lysate(40ug) Lane3:HepG2 whole cell lysate(40ug) Lane4:PC3 whole cell lysate(40ug) Lane5:A549 whole cell lysate(40ug)

Small regulatory polypeptide of amino acid response negatively relates to poor prognosis and controls hepatocellular carcinoma progression via regulating microRNA-5581-3p/human cardiolipin synthase 1

JournalJournal Of Cellular Physiology

ApplicationWB

IF6.384

SpeciesHuman

PMID30825207