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TWIST1 (M1) polyclonal antibody

货号: AP0020

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :AP0020

Product Name :TWIST1 (M1) polyclonal antibody

Swiss-Prot :Q15672

Host :Rabbit

Reactivity :Human,Mouse

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :TWIST1 (M1) polyclonal antibody detects endogenous levels of TWIST1 protein.

BiowMW :~ 22 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Contribution of Soluble Factors to EMT,

Alternative Name :Twist-related protein 1; Class A basic helix-loop-helix protein 38; bHLHa38; H-twist; BHLHA38; TWIST

Immunogen :A synthetic peptide corresponding to amino acids 1-50 of Human TWIST1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of TWIST1 (M1) polyclonal antibody at 1:500 dilution Lane1:Jurkat whole cell lysate(40ug) Lane2:RAW264.7 whole cell lysate(40ug)

Down-regulating ribonuclease inhibitor enhances metastasis of bladder cancer cells through regulating epithelial–mesenchymal transition and ILK signaling pathway

JournalExperimental And Molecular Pathology

ApplicationWB

IF3.362

SpeciesHuman

PMID
lncRNA H19 regulates epithelial–mesenchymal transition and metastasis of bladder cancer by miR-29b-3p as competing endogenous RNA

JournalBiochimica Et Biophysica Acta-Molecular Cell Research

ApplicationWB

IF4.105

SpeciesHuman

PMID28779971