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Sox2 polyclonal antibody

货号: AP0014

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :AP0014

Product Name :Sox2 polyclonal antibody

Swiss-Prot :P48431

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:2000

Background :SOX 2 is also known as SRY related HMG BOX gene 2. All SOX proteins have a single HMG box and bind linear DNA in a sequence-specific manner, resulting in the bending of DNA through large angles. Bending causes the DNA helix to open for some distance, which may affect binding and interactions of other transcription factors. SOX 2 is a transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. SOX2 is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :sox2 polyclonal antibody detects endogenous levels of sox2 protein.

BiowMW :~ 34, 43 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Neuronal and Glial Cell Marker Atlas,ESC Pluripotency and Differentiation Signaling Pathway,

Alternative Name :Transcription factor SOX-2

Immunogen :Synthetic peptide, corresponding to amino acids 100-150 of Human Sox2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Sox2 polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:PC12 whole cell lysate

Nspc1 regulates the key pluripotent Oct4–Nanog–Sox2 axis in P19 embryonal carcinoma cells via directly activating Oct4

JournalBiochemical And Biophysical Research Communications

ApplicationWB

IF3.575

SpeciesMouse

PMID
Oxidative stress inhibits adhesion and transendothelial migration, and induces apoptosis and senescence of induced pluripotent stem cells

JournalClinical And Experimental Pharmacology And Physiology

ApplicationWB

IF2.557

SpeciesMouse

PMID
Effect of in vivo culture conditions on the proliferation and differentiation of rat adipose-derived stromal cells

JournalMECHANISMS OF AGEING AND DEVELOPMENT

ApplicationWB

IF5.3

SpeciesRat

PMID38614143